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簡要描述：6-Mercaptopurine 50-44-2Mercaptopurine (6-mercaptopurine; 6-MP) is an immunosuppressive drug; is a thiopurine.
產品型號：abs816461廠商性質：生產廠家更新時間：2026-02-14訪 問 量：1985產品分類
Product Category詳細介紹
| 品牌 | absin | CAS | 50-44-2 |
|---|---|---|---|
| 分子式 | C5H4N4S | 純度 | ＞98% |
| 分子量 | 152.18 | 貨號 | abs816461 |
| 規(guī)格 | 100mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an immunosuppressive drug | 應用領域 | 化工,生物產業(yè),農林牧漁,制藥/生物制藥,綜合 |
6-Mercaptopurine 50-44-2
| 產品描述 | |
| 描述 | Mercaptopurine (6-mercaptopurine; 6-MP) is an immunosuppressive drug; is a thiopurine. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 6-MP；Mercaptopurine |
| 外觀 | powder |
| 可溶性/溶解性 | DMSO：30mg/ml(197.13 mM) |
| 生物活性 | |
| 靶點 | PRPP Amidotransferase |
| In vitro(體外研究) | Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. |
| In vivo(體內研究) | In the fetal telencephalons of the 6-Mercaptopurine hydrate (6-MP)-treated group, the S phase cell population increases at 36 and 48 h and returns to the control level at 72 h after treatment. The G2/M phase cell population begins to increase at 24 h, peaks at 36 h, decreases at 48 h, and finally returnes to the control level at 72 h. On the other hand, the sub-G1 phase cell population (apoptotic cells) begins to increase at 36 h, peaks at 48 h, and then decreases at 72 h. |
| 參考文獻 | |
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| 研究領域 | |
| 研究領域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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