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| 品牌 | absin | CAS | 3717-88-2 |
|---|---|---|---|
| 分子式 | C24H26ClNO4 | 純度 | 99% |
| 分子量 | 427.92 | 貨號 | abs47027253 |
| 規格 | 25mg | 供貨周期 | 現貨 |
| 主要用途 | used in various urinary syndromes and as | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Flavoxate hydrochloride 3717-88-2
| 產品描述 | |
| 描述 | Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic. |
| 純度 | 99% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | yan酸黃酮哌酯；Rec-7-0040；DW61 |
| 外觀 | 白色或類白色結晶性粉末 |
| 可溶性/溶解性 | DMSO : 3 mg/mL (7.01 mM) Water : 10 mg/mL (23.36 mM) |
| 生物活性 | |
| 靶點 | mAChR |
| In vitro(體外研究) | Flavoxate displaces nitrendipine on the Ca2+ channels binding sites with IC50 of 254 μM. Flavoxate (>10 μM) suppresses carbachol-induced contractions in isolated rat detrusor strips with pD value of 4.55. Flavoxate (>10 μM) suppresses Ca2+-induced contractions in isolated rat detrusor strips with pIC50 value of 4.92. Flavoxate (0.01 μM ?10 μM) inhibits CAMP formation in a concentration-dependent manner in membranes from the rat striatum and cerebral cortex, an action which is completely abolished by pretreating the membranes with pertussis toxin (PTX). Flavoxate causes a concentration-dependent reduction of the K+-induced contraction of human urinary bladder. Flavoxate inhibits the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba2+ currents in a voltage- and concentration-dependent manner with Ki value of 10 μM in human detrusor myocytes. Flavoxate inhibits voltage-dependent nifedipine-sensitive inward Ba2+ currents in human detrusor myocytes at both 30 degrees C (Ki = 5.1 mM) and 37 degrees C (Ki = 4.6 mM). |
| In vivo(體內研究) | Flavoxate (10mg/kg) suppresses both the an initial, rapidly rising phasic contraction (phase 1) and the tonic contraction (phase 2) contractions to the same extent in rats. Flavoxate (10mg/kg) abolishes the bladder contractions without causing any change in the amplitude of the contractions in rats. Flavoxate (3 mg/kg) abolishes the efferent neural activity and the associated bladder contractions for about 10 minutes without changing the baseline vesical pressure in rats. ICV-injected (50 to 200 μg/rat) or IT-injected (100 to 200 μg/rat) Flavoxate abolishes rhythmic bladder contractions during and after injection for five to 15 minutes in a dose-dependent manner in rats. Flavoxate (3 mg/kg, i.v.) abolishes rhythmic bladder contractions and the maximal intervals of voiding contractions is 7.20 min. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領域 | |
| 研究領域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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