Diflunisal 22494-42-4

簡要描述：Diflunisal 22494-42-4
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs.

產品型號：abs47027316
廠商性質：生產廠家
更新時間：2025-12-05
訪問量：836

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Product Category

生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

品牌	absin	CAS	22494-42-4
分子式	C13H8F2O	純度	＞98%
分子量	250.2	貨號	abs47027316
規格	25mg	供貨周期	現貨
主要用途	used to relieve pain accompanied with in	應用領域	化工,生物產業,農林牧漁,制藥/生物制藥,綜合

Diflunisal 22494-42-4

產品描述
描述	Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. .
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	二氟ni柳；二氟苯水楊酸；MK-647
外觀	白色粉末
可溶性/溶解性	DMSO : 50 mg/mL (199.84 mM; Need ultrasonic) Ethanol : 20 mg/mL (79.94 mM)
生物活性
靶點	COX ,p300
In vitro(體外研究)	Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo.
In vivo(體內研究)	Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically.
參考文獻
參考文獻	1. Jeske AH. J Gt Houst Dent Soc. 1999, 71(4):39-40. 2. Mao H, et al. J Am Chem Soc. 2001, 123(43):10429-35. 3. Moore PA, Hersh EV. J Am Dent Assoc. 2001, 132(4):451-6.

研究領域
研究領域	Immunology CancerTumor biomarkers CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery

Diflunisal 22494-42-4溫馨提示：本產品僅作科研實驗使用，不支持臨床等研究

上一篇：abs470273152,2,2-Tribromoethanol 75-80-9
下一篇：abs47027317Amisulpride 71675-85-9

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Diflunisal 22494-42-4

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