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| 品牌 | absin | CAS | 4342-03-4 |
|---|---|---|---|
| 分子式 | C6H10N6O | 純度 | ＞98% |
| 分子量 | 182.18 | 貨號 | abs47027506 |
| 規格 | 25mg | 供貨周期 | 現貨 |
| 主要用途 | used in the treatment of various cancers | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Dacarbazine 4342-03-4
| 產品描述 | |
| 描述 | Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 達ka巴嗪；Imidazole Carboxamide |
| 外觀 | 微黃色結晶或粉末 |
| 可溶性/溶解性 | DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶點 | DNA polymerase beta |
| In vitro(體外研究) | Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway. |
| In vivo(體內研究) | Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領域 | |
| 研究領域 | CancerCancer Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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