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| 品牌 | absin | CAS | 14698-29-4 |
|---|---|---|---|
| 分子式 | C13H11NO5 | 純度 | 98% |
| 分子量 | 261.24 | 貨號 | abs47027571 |
| 規格 | 500mg | 供貨周期 | 現貨 |
| 主要用途 | is a potent inhibitor of DNA gyrase | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Oxolinic acid 14698-29-4
| 產品描述 | |
| 描述 | Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 惡喹酸 |
| 外觀 | 白色至類白色固體 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點 | bacterial DNA gyrase,DNA synthesis,dopamine uptake |
| In vitro(體外研究) | Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml. |
| In vivo(體內研究) | The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領域 | |
| 研究領域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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