ML130 (Nodinitib-1) 799264-47-4

簡要描述：ML130 (Nodinitib-1) 799264-47-4
ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.

產品型號：abs47028324
廠商性質：生產廠家
更新時間：2026-01-29
訪問量：960

產品咨詢聯系我們

Product Category

生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

品牌	absin	CAS	799264-47-4
分子式	C14H13N3O2S	純度	＞98%
分子量	287.34	貨號	abs47028324
規格	10mg	供貨周期	現貨
主要用途	is a potent and selective inhibitor of N	應用領域	化工,生物產業,農林牧漁,制藥/生物制藥,綜合

ML130 (Nodinitib-1) 799264-47-4

產品描述
描述	ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	ML130; CID-1088438
外觀	white to beige powder
可溶性/溶解性	DMSO : 28.7 mg/mL (100 mM) Ethanol : 2.9 mg/mL (10 mM)
生物活性
靶點	NOD1; NOD2; TNF-α;
In vitro(體外研究)	ML130 has shown selective inhibition of NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity and is selected as a probe candidate molecule. ML130 is also confirmed in secondary assays by selectively inhibiting NOD1-dependent IL-8 secretion and also selectively inhibiting the NOD1-dependent pathway to NF-κB activation. In another research, ML130 is proved to cause conformational changes of NOD1 in vitro and alter NOD1 subcellular targeting in cells, providing chemical probes for interrogating mechanisms regulating NOD1 activity and tools for exploring the roles of NOD1 in various infectious and inflammatory diseases.
參考文獻
參考文獻