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| 品牌 | absin | CAS | 1440898-61-2 |
|---|---|---|---|
| 分子式 | C40H37N5O | 純度 | 98% |
| 分子量 | 603.75 | 貨號 | abs47028338 |
| 規格 | 10mg | 供貨周期 | 現貨 |
| 主要用途 | is a small molecular inhibitor of KRAS-P | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Deltarasin 1440898-61-2
| 產品描述 | |
| 描述 | Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:100 mg/mL (165.63 mM) |
| 生物活性 | |
| 靶點 | PDEδ |
| In vitro(體外研究) | In liver cells, Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. |
| In vivo(體內研究) | Deltarasin (10 mg/kg i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts. |
| 參考文獻 | |
| 參考文獻 |
| 研究領域 | |
| 研究領域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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