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| 品牌 | absin | CAS | 122841-12-7 |
|---|---|---|---|
| 分子式 | C19H22N8O6S2.H2SO4 | 純度 | 98% |
| 分子量 | 620.64 | 貨號 | abs47028341 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a widely used beta-lactam antibiotic. | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Cefoselis Sulfate 122841-12-7
| 產品描述 | |
| 描述 | Cefoselis is a widely used beta-lactam antibiotic. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:3 mg/mL (4.83 mM) |
| 生物活性 | |
| In vitro(體外研究) | Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. |
| In vivo(體內研究) | Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. |
| 參考文獻 | |
| 參考文獻 |
| 研究領域 | |
| 研究領域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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