全國服務(wù)咨詢熱線：
18860915427
18860915427
簡要描述：Bisacodyl 603-50-9Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
產(chǎn)品型號：abs47028375廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-02-02訪 問 量：1071產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 603-50-9 |
|---|---|---|---|
| 分子式 | C22H19NO4 | 純度 | ＞98% |
| 分子量 | 361.39 | 貨號 | abs47028375 |
| 規(guī)格 | 50mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a stimulant laxative drug | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Bisacodyl 603-50-9
| 產(chǎn)品描述 | |
| 描述 | Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 比sha可啶 |
| 外觀 | 白色或類白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 67 mg/mL (185.4 mM) |
| 生物活性 | |
| In vitro(體外研究) | Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. |
| In vivo(體內(nèi)研究) | Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產(chǎn)品咨詢
地址：上海市浦東新區(qū)新浩路58號申江科創(chuàng)園18棟
郵箱：fengmj@univ-bio.com
傳真：
電話
微信掃一掃