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| 品牌 | absin | CAS | 1374356-45-2 |
|---|---|---|---|
| 分子式 | C21H22Cl2FN5O | 純度 | 98% |
| 分子量 | 450.34 | 貨號 | abs47028403 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a potent MTH1 (NUDT1) inhibitor with | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
(S)-crizotinib 1374356-45-2
| 產品描述 | |
| 描述 | (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:42 mg/mL warmed (93.26 mM) |
| 生物活性 | |
| 靶點 | MTH1 |
| In vitro(體外研究) | (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells. |
| In vivo(體內研究) | (S)-Crizotinib (50?mg/kg, orally, daily) impairs tumor growth in an SW480 colon carcinoma xenograft model. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領域 | |
| 研究領域 | EpigeneticsDNA / RNADNA Damage & RepairBase Excision Repair Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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