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簡要描述：Loxistatin Acid (E-64C) 76684-89-4E-64c, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
產(chǎn)品型號：abs47028413廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-02-03訪 問 量：1016產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 76684-89-4 |
|---|---|---|---|
| 分子式 | C15H26N2O5 | 純度 | 98% |
| 分子量 | 314.38 | 貨號 | abs47028413 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an irreversible and membrane-permeant | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Loxistatin Acid (E-64C) 76684-89-4
| 產(chǎn)品描述 | |
| 描述 | E-64c, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Loxistatin Acid；E-64-C；E 64c；阿洛司他丁酸 |
| 外觀 | 白色粉末 |
| 可溶性/溶解性 | DMSO : 58 mg/mL (184.5 mM) Ethanol : 58 mg/mL (184.5 mM) Water : 2 mg/mL (6.36 mM) |
| 生物活性 | |
| 靶點(diǎn) | cysteine protease |
| In vitro(體外研究) | Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. |
| In vivo(體內(nèi)研究) | In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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