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| 品牌 | absin | CAS | N/A |
|---|---|---|---|
| 分子式 | C223H330N80O51 | 純度 | 98% |
| 分子量 | 4947.51 | 貨號 | abs816217 |
| 規格 | 1mg | 供貨周期 | 現貨 |
| 主要用途 | is a specific STAT3-binding peptide | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
| 產品描述 | |
| 描述 | APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外觀 | powder |
| 可溶性/溶解性 | DMSO ：10 mg/mL (2.02 mM) Water ：100 mg/mL (20.21 mM) |
| 生物活性 | |
| 靶點 | STAT3 |
| In vitro(體外研究) | Previous study showed that APTSTAT3-9R bound to STAT3 with high specificity and affinity. Moreover, the addition of a cell-penetrating motif to the peptide to yield APTSTAT3-9R enabled uptake by murine B16F1 melanoma cells. In addition, treatment of various types of cancer cells with APTSTAT3-9R was able to inhibit STAT3 phosphorylation and reduce expression of STAT targets, such as Bcl-xL, cyclin D1, and survivin. As a result, APTSTAT3-9R could suppress the viability and proliferation of cancer cells. |
| In vivo(體內研究) | In a previous animal in vivo study, a human lung carcinoma xenograft model was prepared by subcutaneous implantation of A549 cancer cells. After tumors had reached a volume of approximately 50 mm3 after two weeks, APTSTAT3-9R was intratumorally injected every other day for a total of four injections. Results showed that the tumor burden was significantly reduced in the APTSTAT3-9R–treated group when compared with that in the control group; however, there was little difference in tumor size between APTscr-9R and control groups . |
| 研究領域 | |
| 研究領域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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