ICG-001 780757-88-2；847591-62-2

簡要描述：ICG-001 780757-88-2；847591-62-2
ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF

產品型號：abs810420a
廠商性質：生產廠家
更新時間：2026-02-05
訪問量：1262

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Product Category

生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

品牌	absin	CAS	780757-88-2；847591-62-2
分子式	C33H32N4O4	純度	＞98%
分子量	548.63	貨號	abs810420
規格	5mg	供貨周期	現貨
主要用途	is a small-molecule antagonist of b-cate	應用領域	化工,生物產業,農林牧漁,制藥/生物制藥,綜合

ICG-001 780757-88-2；847591-62-2

產品描述
描述	ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding pro
純度	>98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	ICG001；ICG 001
外觀	Off-white powder
可溶性/溶解性	DMSO ：100 mg/mL (182.27 mM) Ethanol ：10 mg/mL (18.22 mM)
生物活性
靶點	Wnt/β-catenin
In vitro(體外研究)	PRI-724 binds specifically to CBP but not the related transcriptional coactivator p300, thereby disrupting the interaction of CBP with β-catenin. Treatment with PRI-724 selectively induces apoptosis in colon carcinoma cells but not in normal colonic epithelial cells and reduces in vitro growth of colon carcinoma cells.
In vivo(體內研究)	PRI-724 exhibits antitumor activity in the mouse xenograft models of colon cancer. The initial results of the Phase I clinic trial of PRI-724 has been disclosed publically. The drug exhibits an acceptable toxicity profile with only one dose-limiting toxicity of grade 3 reversible hyperbilirubinaemia. An Open-Label dose-escalation phase I/II study of PRI-724 for patients with advanced myeloid malignancies is still ongoing.