全國服務(wù)咨詢熱線：
18860915427
18860915427
簡要描述：Omecamtiv mecarbil (CK-1827452) 873697-71-3Omecamtivmecarbil (CK-1827452) is a specific cardiac myosinactivator and a clinical drug for left ventricular systolic heart failure.
產(chǎn)品型號(hào)：abs810613廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-02-05訪 問 量：1242產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 873697-71-3 |
|---|---|---|---|
| 分子式 | C20H24FN5O3 | 純度 | ＞98% |
| 分子量 | 401.43 | 貨號(hào) | abs810613 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a specific cardiac myosinactivator | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Omecamtiv mecarbil (CK-1827452) 873697-71-3
| 產(chǎn)品描述 | |
| 描述 | Omecamtivmecarbil (CK-1827452) is a specific cardiac myosinactivator and a clinical drug for left ventricular systolic heart failure. |
| 純度 | >98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | CK-1827452, CK1827452,CK 1827452 |
| 外觀 | Powder |
| 可溶性/溶解性 | DMSO 80 mg/mL (199.28 mM) Ethanol 6 mg/mL (14.94 mM) |
| 生物活性 | |
| 靶點(diǎn) | Myosin ATPase |
| In vitro(體外研究) | In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. |
| In vivo(體內(nèi)研究) | Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Signal TransductionCytoskeleton / ECMCytoskeletonMotor ProteinsMyosin Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產(chǎn)品咨詢
地址：上海市浦東新區(qū)新浩路58號(hào)申江科創(chuàng)園18棟
郵箱：fengmj@univ-bio.com
傳真：
電話
微信掃一掃