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Product Category詳細介紹
| 品牌 | absin | CAS | 1253952-02-1 |
|---|---|---|---|
| 分子式 | C28H29Cl2N3O3 | 純度 | ≥98% |
| 分子量 | 526.45 | 貨號 | abs818493 |
| 規格 | 2mg | 供貨周期 | 現貨 |
| 主要用途 | 是ROCK抑制劑 | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
AR-13324 hydrochloride 1253952-02-1
| 產品描述 | |
| 描述 | AR-13324是ROCK抑制劑，Ki值為0.2-10.3 nM。 |
| 純度 | ≥98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 奈他地爾;Netarsudil hydrochloride；Netarsudil (AR-13324) 2HCl |
| 外觀 | White to off white powder |
| 可溶性/溶解性 | DMSO ：20 mg/mL (37.99 mM) |
| 生物活性 | |
| 靶點 | ROCK |
| In vitro(體外研究) | Previous study showed that at the cellular level, netarsudil had been shown to be able to induce loss of actin stress fibers, cell shape changes, loss of focal adhesions, as well as changes in extracellular matrix composition of TM cells. |
| In vivo(體內研究) | Animal efficacy study found that the topical treatment of netarsudil was able to affect both proximal (trabecular meshwork and Schlemm's Canal) and distal portions (intrascleral vessels) of the mouse conventional outflow tract. |
| 研究領域 | |
| 研究領域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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