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簡要描述：AT13148 1056901-62-2AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
產(chǎn)品型號：abs811173廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-02-24訪 問 量：2162產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1056901-62-2 |
|---|---|---|---|
| 分子式 | C17H16ClN3O | 純度 | ＞98% |
| 分子量 | 313.78 | 貨號 | abs811173 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a novel oral multi-AGC kinase inhibi | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
AT13148 1056901-62-2
| 產(chǎn)品描述 | |
| 描述 | AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | AT 13148；AT-13148 |
| 可溶性/溶解性 | DMSO Solubility: 62 mg/mL (197.59 mM) |
| 生物活性 | |
| 靶點 | PKA,ROCK2,ROCK1,p70S6K,Akt1 |
| In vitro(體外研究) | AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling. |
| In vivo(體內(nèi)研究) | AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Epigenetics CancerCell DeathApoptosisMetabolism CancerSignal transductionProtein phosphorylationSerine/threonine kinasesAKT EpigeneticsCell cycleApoptosisNuclear MetabolismPathways and ProcessesMetabolism processesApoptosis Signal TransductionProtein PhosphorylationSer / Thr KinasesPKB / AKT Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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