LY2090314 603288-22-8

簡(jiǎn)要描述：LY2090314 603288-22-8
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.

產(chǎn)品型號(hào)：abs810372
廠商性質(zhì)：生產(chǎn)廠家
更新時(shí)間：2026-02-24
訪問量：2102

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品牌	absin	CAS	603288-22-8
分子式	C28H25FN6O3	純度	＞98%
分子量	512.53	貨號(hào)	abs810372
規(guī)格	5mg	供貨周期	現(xiàn)貨
主要用途	is a potent inhibitor of glycogen syntha	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

LY2090314 603288-22-8

產(chǎn)品描述
描述	LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
純度	＞98%
儲(chǔ)存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	LY 2090314；LY-2090314
外觀	yellow to orange powder
可溶性/溶解性	DMSO : 93 mg/mL (181.5 mM) Ethanol : 2 mg/mL warmed (3.9 mM)
生物活性
靶點(diǎn)	GSK-3β；GSK-3α
In vitro(體外研究)	LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.
In vivo(體內(nèi)研究)	LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts.