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| 品牌 | absin | CAS | 146986-50-7 |
|---|---|---|---|
| 分子式 | C14H21N3O | 純度 | ≥98% |
| 分子量 | 247.34 | 貨號 | abs812864 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a selective ROCK1 (p160ROCK) inhibito | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Y-27632 146986-50-7
| 產品描述 | |
| 描述 | Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over Others kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| 純度 | ≥98% |
| 儲存/保存方法 | Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Y 27632；Y-27632 |
| 外觀 | White Powder |
| 可溶性/溶解性 | DMSO : ≥ 32 mg/mL (129.38 mM) |
| 生物活性 | |
| 靶點 | ROCK-I；ROCK-II；PKN；PKCα；PKA；Citron kinase |
| In vitro(體外研究) | Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 µM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 µM Y-27632 induced group. |
| In vivo(體內研究) | Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group). |
| 研究領域 | |
| 研究領域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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