（-）MK-801 maleate 121917-57-5

簡要描述：（-）MK-801 maleate 121917-57-5
(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .

產品型號：abs810778
廠商性質：生產廠家
更新時間：2026-02-25
訪問量：1693

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生化試劑

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品牌	absin	CAS	121917-57-5
分子式	C20H19NO4	純度	＞98%
分子量	337.37	貨號	abs810778
規格	10mg	供貨周期	現貨
主要用途	is the enantiomer of (+)-MK-801	應用領域	化工,生物產業,農林牧漁,制藥/生物制藥,綜合

（-）MK-801 maleate 121917-57-5

產品描述
描述	(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .
純度	>98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	MK 801; MK801; C13737
外觀	Powder
可溶性/溶解性	DMSO：67 mg/mL (198.59 mM) Ethanol：7 mg/mL (20.74 mM)
生物活性
靶點	NMDA receptor
In vitro(體外研究)	Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant.
In vivo(體內研究)	All the control rats have severe permanent neurological deficits after ischemic spinal cord injury (ISCI), whereas the dizocilpine–treated rats have statistically (P
參考文獻
參考文獻	[1] Wong EH et al., Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108. [2] Wise-Faberowski L et al., J Neurosurg Anesthesiol, 2006, 18(4), 240-246. [3] Kocaeli H et al., Surg Neurol, 2005, 64 Suppl 2, S22-S26.