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| 品牌 | absin | CAS | 133550-30-8 |
|---|---|---|---|
| 分子式 | C17H14N2O3 | 純度 | ＞98% |
| 分子量 | 294.3 | 貨號 | abs810014 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | 是一種EGFR抑制劑 | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
AG 490 133550-30-8
| 產品描述 | |
| 描述 | AG-490 (Tyrphostin B42)是一種EGFR抑制劑，在無細胞試驗中IC50為0.1μM，作用于EGFR比作用于ErbB2選擇性高135倍，對JAK2也有抑制作用，對Lck，Lyn，Btk，Syk和Src沒有抑制活性。 |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | AG 490; Tyrphostin AG 490; AG490; Zinc02557947;AG-490 (Tyrphostin B42) |
| 外觀 | yellow solid |
| 可溶性/溶解性 | DMSO：58 mg/mL (197.07 mM) Ethanol：6 mg/mL (20.38 mM) |
| 生物活性 | |
| 靶點 | EGFR |
| In vivo(體內研究) | AG490 significantly inhibits the development of type 1 diabetes (T1D) (p?=?0.02, p?=?0.005; at two different time points). Monotherapy of newly diagnosed diabetic NOD mice with AG490 (1 mg/mouse) markedly results in disease remission in treated animals (n=23) in comparision to the absolute inability (0%; 0/10, p=0.003, Log-rank test) of DMSO and sustained eugluycemia is maintained for several months following drug withdrawal. AG490 (1-10 µg) significantly attenuates ?-carrageenan-induced thermal hyperalgesia in a dose-dependent manner. AG490 also reduces mechanical hyperalgesia. |
| 參考文獻 | |
| 參考文獻 | [1] Gazit A, et al. J Med Chem, 1991, 34(6), 1896-1907. [2] Meydan N, et al. Nature, 1996, 379(6566), 645-648. [3] Nielsen M, et al. Proc Natl Acad Sci U S A, 1997, 94(13), 6764-6769. [4] Kirken RA, et al. J Leukoc Biol, 1999, 65(6), 891-899. [5] Sun X, et al. Blood, 2001, 97(7), 2008-2015. [6] Burdelya L, et al. Mol Cancer Ther, 2002, 1(11), 893-899. [7] Samanta AK, et al. Cancer Res, 2006, 66(13), 6468-6472. [8] Abe M, et al. Int Immunopharmacol, 2009, 9(7-8), 870-877. |
| 研究領域 | |
| 研究領域 | CancerGrowth factorsEGF CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors CancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinases CancerTumor biomarkersReceptors Cell CycleCell differentiation MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionGrowth Factors/HormonesEGF Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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