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Product Category詳細介紹
| 品牌 | absin | CAS | 163252-36-6 |
|---|---|---|---|
| 分子式 | C10H13FN2O5 | 純度 | 98% |
| 分子量 | 260.22 | 貨號 | abs47028313 |
| 規格 | 10mg | 供貨周期 | 現貨 |
| 主要用途 | is an antiviral drug for the treatment | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Clevudine 163252-36-6
| 產品描述 | |
| 描述 | Clevudine is an antiviral drug for the treatment of hepatitis B. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:52 mg/mL (199.83 mM) |
| 生物活性 | |
| 靶點 | RNA polymerase,DNA polymerase |
| In vitro(體外研究) | Clevudine is a potent antiviral agent against HBV (EC50 0.1 μM in HepG2 2.2.15 cells) as well as EBV, which has low cytotoxicities in a variety of cell lines including MT2, CEM, H1 and HepG2 2.2.15 and bone marrow progenitor cells. Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate. Clevudine is known to act specifically on viral DNA synthesis, and its triphosphate inhibits the HBV DNA synthesis in a dose-dependent manner without being incorporated into the DNA or chain termination. Clevudine results in increase of the amounts of the diphosphate and triphosphate metabolites of these analogs. Clevudine monophosphate (L-FMAUMP) is a poorer substrate than its D-configuration anomer. Clevudine is readily phosphorylated to the corresponding 5'-triphosphate form of the compound in cell culture, which involves the mechanism of action of Clevudine. |
| In vivo(體內研究) | Clevudine is a potent antiviral agent against HBV (EC50 0.1 μM in HepG2 2.2.15 cells) as well as EBV, which has low cytotoxicities in a variety of cell lines including MT2, CEM, H1 and HepG2 2.2.15 and bone marrow progenitor cells. Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate. Clevudine is known to act specifically on viral DNA synthesis, and its triphosphate inhibits the HBV DNA synthesis in a dose-dependent manner without being incorporated into the DNA or chain termination. Clevudine results in increase of the amounts of the diphosphate and triphosphate metabolites of these analogs. Clevudine monophosphate (L-FMAUMP) is a poorer substrate than its D-configuration anomer. Clevudine is readily phosphorylated to the corresponding 5'-triphosphate form of the compound in cell culture, which involves the mechanism of action of Clevudine. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領域 | |
| 研究領域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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