全國服務咨詢熱線：
18860915427
18860915427
簡要描述：Flupirtine maleate 75507-68-5Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener
產(chǎn)品型號：abs47028314廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-01-29訪 問 量：963產(chǎn)品分類
Product Category詳細介紹
| 品牌 | absin | CAS | 75507-68-5 |
|---|---|---|---|
| 分子式 | C15H17FN4O2.C4H4O4 | 純度 | ＞99% |
| 分子量 | 420.39 | 貨號 | abs47028314 |
| 規(guī)格 | 100mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is the salt form of Flupirtine | 應用領域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Flupirtine maleate 75507-68-5
| 產(chǎn)品描述 | |
| 描述 | Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
| 純度 | ＞99% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 馬來酸氟吡汀；Katadolon；D-9998 |
| 外觀 | 白色或類白色結晶性粉末 |
| 可溶性/溶解性 | DMSO : 42 mg/mL (100 mM) Ethanol : 4.2 mg/mL (10 mM) |
| 生物活性 | |
| 靶點 | NMDA receptor,Potassium channel |
| In vitro(體外研究) | Flupirtine pre-incubated for 2 hours prevents cell death in rat cortical neurons induced by NMDA and gp120 of HIV-1. Flupirtine is capable of protecting primary neurons against glutamate-induced cytotoxicity by reducing calcium ion concentrations at 1-10 mM. Flupirtine pretreated for 2 hours preventsβ-amyloid-induced apoptosis in primary neuronal cells at concentrations of 1 or 5μg/mL. Flupirtine at concentration of 10 μM markedly decreases nonreceptor-mediated necrotic cell death in PC 12 cultures treated with 10 mM L-glutamate, meanwhile, Flupirtine exerts anti-oxidative effects in PC 12 cultures. Flupirtine-maleate at concentrations of 1 μM and 10 μM decreases TRAIL-mediated death of human living brain tissue culture. Flupirtine activates inwardly rectifying potassium ion channels and thus stabilizes the resting membrane potential at a therapeutically relevant concentration. |
| In vivo(體內(nèi)研究) | Pre-treatment with Flupirtine exerts a protective effect on hippocampal and striatal neuronal damage and on deficits in spatial learning in rats with cerebral ischemia. Flupirtine administered centrally inhibits the nociceptive responses induced by chemical, thermal, mechanical and electrical stimuli in animal studies. Flupirtine exerts muscle relaxant effects in rat. |
| 參考文獻 | |
| 參考文獻 |
| 研究領域 | |
| 研究領域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產(chǎn)品咨詢
地址：上海市浦東新區(qū)新浩路58號申江科創(chuàng)園18棟
郵箱：fengmj@univ-bio.com
傳真：
電話
微信掃一掃