全國(guó)服務(wù)咨詢熱線：
18860915427
18860915427
簡(jiǎn)要描述：SecinH3 853625-60-2SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respect
產(chǎn)品型號(hào)：abs47028408廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-02-03訪 問 量：1028產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 853625-60-2 |
|---|---|---|---|
| 分子式 | C24H20N4O4S | 純度 | ＞98% |
| 分子量 | 460.5 | 貨號(hào) | abs47028408 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a selective cytohesin inhibitor with | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
SecinH3 853625-60-2
| 產(chǎn)品描述 | |
| 描述 | SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide |
| 外觀 | 白色固體 |
| 可溶性/溶解性 | DMSO : 46.1 mg/mL (100 mM) Ethanol : 4.6 mg/mL (10 mM), with gentle warming |
| 生物活性 | |
| 靶點(diǎn) | hCyh2,hCyh1,mCyh3,hCyh3,drosophila steppke,, |
| In vitro(體外研究) | In HepG2 cells, SecinH3 inhibits insulin signaling and associated gene expression. SecinH3 also markedly inhibits migration of preadipocyte 3T3-L1 cells. In the A549 cells, SecinH3 results in reduced proliferation by indirectly attenuating EGFR activation, and causes a synergistic antiproliferative effect when used in combination with gefitinib. |
| In vivo(體內(nèi)研究) | In mice, SecinH3 increases the expression of gluconeogenic genes, reduces the expression of glycolytic, fatty acid and ketone body metabolism genes in the liver, reduces liver glycogen stores, and increases plasma insulin. In mice bearing H460 xenografts, SecinH3 significantly retards tumor growth through its antiproliferative and pro-apoptotic effect. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Metabolism CancerCancer Metabolism NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產(chǎn)品咨詢
地址：上海市浦東新區(qū)新浩路58號(hào)申江科創(chuàng)園18棟
郵箱：fengmj@univ-bio.com
傳真：
電話
微信掃一掃