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簡(jiǎn)要描述：SF1670 345630-40-2SF1670是一種高度有效且專一的PTEN的抑制劑，其IC50 為 2 μM。
產(chǎn)品型號(hào)：abs47028409廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-02-03訪 問 量：1113產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 345630-40-2 |
|---|---|---|---|
| 分子式 | C19H17NO3 | 純度 | ＞98% |
| 分子量 | 307.34 | 貨號(hào) | abs47028409 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | 是一種高度有效且專一的PTEN的抑制劑 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
SF1670 345630-40-2
| 產(chǎn)品描述 | |
| 描述 | SF1670是一種高度有效且專一的PTEN的抑制劑，其IC50 為 2 μM。 |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外觀 | Red-violet solid |
| 可溶性/溶解性 | DMSO ：30.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶點(diǎn) | PTEN |
| In vitro(體外研究) | SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions. |
| In vivo(體內(nèi)研究) | Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCell cycleKinases/phosphatasesPhosphatases CancerOncoproteins/suppressorsTumor suppressorsPTEN pathway Cell CycleKinases/PhosphatasesPhosphatases EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors MetabolismTypes of diseaseDiabetes MetabolismTypes of diseaseMetabolic disorders MetabolismTypes of diseaseObesity NeuroscienceDevelopment Signal TransductionSignaling PathwayLipid SignalingLipid Phosphatases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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