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| 品牌 | absin | CAS | 1809784-29-9 |
|---|---|---|---|
| 分子式 | C26H35N7O5 | 純度 | ＞98% |
| 分子量 | 525.6 | 貨號 | abs814545 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a selective GADD45β/MKK7 inhibitor | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
DTP3 1809784-29-9
| 產品描述 | |
| 描述 | DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | DTP 3 |
| 外觀 | powder |
| 可溶性/溶解性 | DMSO ：100 mg/mL (190.26 mM) Water ：100 mg/mL (190.26 mM) |
| 生物活性 | |
| 靶點 | GADD45β,MKK7 |
| In vitro(體外研究) | DTP3 physically interacts with MKK7, both in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.21 in U266 cells and of 0.56 in KMS-12 cells. |
| In vivo(體內研究) | DTP3 (14.5 mg/kg/day) exhibits potent antitumor activity against MM in mouse plasmacytoma model. |
| 研究領域 | |
| 研究領域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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