Emricasan 254750-02-2

Name: Emricasan 254750-02-2abs816139
Brand: absin
Price: 1087 CNY
Availability: InStock

簡要描述：Emricasan 254750-02-2
Emricasan is a potent irreversible pan-caspase inhibitor.

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詳細介紹

品牌	absin	CAS	254750-02-2
分子式	C26H27F4N3O7	純度	99.00 %
分子量	569.50	貨號	abs816139
規格	5mg	供貨周期	現貨
主要用途	is a potent irreversible pan-caspase inh	應用領域	化工,生物產業,農林牧漁,制藥/生物制藥,綜合

Emricasan 254750-02-2

產品描述
描述	Emricasan is a potent irreversible pan-caspase inhibitor.
純度	99.00 %
儲存/保存方法	store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
基本信息
可溶性/溶解性	體外: DMSO 100mg/mL(175.59mM) Ethanol 100mg/mL(175.59mM) Water <1mg/mL
生物活性
靶點	caspase
In vitro(體外研究)	Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.
In vivo(體內研究)	Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.
參考文獻
參考文獻	[1] Barreyro FJ, et al. Liver Int. 2015, 35(3):953-66. [2] Xu M, et al. Nat Med. 2016, [Epub ahead of print].