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| 品牌 | absin | CAS | 1421373-65-0 |
|---|---|---|---|
| 分子式 | C28H33N7O2 | 純度 | ＞98% |
| 分子量 | 499.61 | 貨號 | abs810718 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a potent and selective mutated forms | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
AZD-9291 1421373-65-0
| 產品描述 | |
| 描述 | AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | EGFR inhibitor; AZD9291; AZD 9291;Tagrisso;Osimertinib; Mereletinib |
| 外觀 | Powder |
| 可溶性/溶解性 | DMSO ：99 mg/mL warmed (198.15 mM) Ethanol ：43 mg/mL warmed (86.06 mM) |
| 生物活性 | |
| 靶點 | L858R/T790M EGFR ,Exon 19 deletion EGFR ,WT EGFR |
| In vitro(體外研究) | AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro. |
| In vivo(體內研究) | AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo. |
| 研究領域 | |
| 研究領域 | CancerGrowth factorsEGF CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors CancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinases CancerTumor biomarkersReceptors Cell CycleCell differentiation MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionGrowth Factors/HormonesEGF Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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