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簡(jiǎn)要描述：BAY11-7085 196309-76-9BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
產(chǎn)品型號(hào)：abs812008廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-02-25訪 問(wèn) 量：2464產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 196309-76-9 |
|---|---|---|---|
| 分子式 | C13H15NO2S | 純度 | ＞98% |
| 分子量 | 249.33 | 貨號(hào) | abs812008 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an irreversible inhibitor of TNFα-ind | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
BAY11-7085 196309-76-9
| 產(chǎn)品描述 | |
| 描述 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | BAY 11-7085；BAY-11-7085；BAY 11-7083 |
| 外觀 | white solid |
| 可溶性/溶解性 | DMSO : 24.9 mg/mL (100 mM) Ethanol : 24.9 mg/mL (100 mM) |
| 生物活性 | |
| 靶點(diǎn) | IκBα phosphorylation |
| In vitro(體外研究) | BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells. |
| In vivo(體內(nèi)研究) | BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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